Divergent Synthesis of Dihydroxanthene-Hemicyanine\nFused Near-Infrared Fluorophores through the Late-Stage Amination\nof a Bifunctional Precursor

Abstract

A late-stage amination\nof a bifunctional dihydroxanthene (DHX)\nscaffold is reported to access a wide variety of new near-infrared\n(NIR) chromophores/fluorophores. The divergent approach allows the\ncoupling of aliphatic and aromatic amines and readily provides molecular\ndiversity shedding light on the structure–fluorescence relationship\nof this emerging class of NIR fluorophores.