Concepedia

Bifunctional Molecules

Bifunctional Molecules is a chemical modality comprising a single molecular entity engineered with two distinct functional domains that simultaneously engage two separate target proteins to induce or stabilize specific protein–protein interactions, thereby enabling targeted modulation of intracellular signaling pathways.

636

Publications

36.1K

Citations

3.1K

Authors

825

Institutions

Publications per year

2017–2026

151

Parents

Publications

636

The Cytolytic P <sub>2Z</sub> Receptor for Extracellular ATP Identified as a P <sub>2X</sub> Receptor (P2X <sub>7</sub> )

Annmarie Surprenant, Eric Kawashima, R. Alan North et al. · Science · 1996 · 1.7K citations

, , +15

Synthesis and reactions of functionalised gold nanoparticles

Mathias Brust, J. Fink, Donald Bethell et al. · Journal of the Chemical Society Chemical Communications · 1995 · 1.1K citations

, , +17

Ring closure reactions of bifunctional chain molecules

Gabriello Illuminati, Luigi Mandolini · Accounts of Chemical Research · 1981 · 970 citations

, , +8

Fluoride Ion Recognition by Chelating and Cationic Boranes

Todd W. Hudnall, Ching‐Wen Chiu, François P. Gabbaı̈ · Accounts of Chemical Research · 2009 · 516 citations

, , +14

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

Adam D. Cotton, Duy Nguyen, Josef A. Gramespacher et al. · Journal of the American Chemical Society · 2021 · 507 citations · Full text

, , +17

1–5 of 636

Authors

3.1K

  1. AZ
    A. Zlatkis

    University of Houston, United States

    7 publications · 204 citations

    7

    h-index

  2. SF
    Stacey F. Bent

    Stanford University, United States

    7 publications · 256 citations

    7

    h-index

  3. CF
    Colin F. Poole

    Wayne State University, United States

    7 publications · 204 citations

    7

    h-index

  4. SS
    S. Singhawangcha

    University of Houston, United States

    6 publications · 128 citations

    6

    h-index

  5. FP
    Frank Porreca

    University of Arizona, United States

    5 publications · 175 citations

    5

    h-index

1–5 of 3.1K

Institutions

825

  1. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    113 publications

    4K citations

  2. Chinese Academy of Sciences

    Beijing, China

    12 h-index

    59 publications

    5.2K citations

  3. Stanford University

    Stanford, United States

    12 h-index

    45 publications

    2.5K citations

  4. Harvard University

    Cambridge, United States

    9 h-index

    35 publications

    2.6K citations

  5. University of Michigan

    Ann Arbor, United States

    8 h-index

    42 publications

    4.4K citations

  6. University of Houston

    Houston, United States

    8 h-index

    27 publications

    651 citations

  7. Yale University

    New Haven, United States

    7 h-index

    40 publications

    6.1K citations

  8. University of British Columbia

    Vancouver, Canada

    6 h-index

    20 publications

    1.7K citations

1–8 of 825

Venues

  1. Journal of the American Chemical Society

    JACS · 32 publications · 3.4K citations

    27

    h-index

  2. Journal of Medicinal Chemistry

    22 publications · 1.3K citations

    19

    h-index

  3. Inorganic Chemistry

    17 publications · 735 citations

    15

    h-index

  4. Angewandte Chemie International Edition

    15 publications · 1.3K citations

    15

    h-index

  5. The Journal of Organic Chemistry

    JOC · 18 publications · 774 citations

    15

    h-index

1–5