Concepedia

Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity

Xingfeng Liu, Kai Wang, Luhai Wang, Lijuan Kong, Shaocong Hou, Yanjun Wan, Chunxiao Ma, Jingwen Chen, Xiaowei Xing, Caiyi Xing,

Hepatology · 2022 · 31 citations · 15 references

DOI

Abstract

LTB4/Ltb4r1 promotes hepatocyte lipogenesis directly by activating PKA-IRE1α-XBP1s to promote lipogenic gene expression. Inhibition of hepatocyte Ltb4r1 improved hepatic steatosis and insulin resistance. Ltb4r1 is a potential therapeutic target for NAFLD.

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Obesity, Metabolic Syndrome, Metabolic Associated Steatohepatitis +13

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Glucose Tracer Infusion, Metabolic Disorder, Pathology +22

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