Concepedia

Prognostic Role of Targeted Methylation Analysis in Paraffin-embedded Samples of Adrenocortical Carcinoma

Juliane Lippert, Barbara Altieri, Breanna Morrison, Sonja Steinhauer, Gabrielle Smith, Antonia Lorey, Hanna Urlaub, Stefan Kircher, Alice Sitch, Cristina L. Ronchi

The Journal of Clinical Endocrinology & Metabolism · 2022 · 14 citations · 20 references

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Abstract

This study demonstrated that hypermethylation in PAX5 is associated with worst clinical outcome in ACC, even after accounting for S-GRAS score. Assessing methylation in FFPE material is straightforward in the clinical setting and could be used to improve accuracy of prognostic classification, enabling the direction of personalized management.

References

20

Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer

Reiki Nishimura, Tomofumi Osako, Yasuyuki Nishiyama et al. · Oncology · 2013 · 13.2K citations · Full text

Evaluating the Yield of Medical Tests

Frank E. Harrell · JAMA · 1982 · 3.3K citations

European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors

Olaf M. Dekkers, Tobias Else, Eric Baudin et al. · European Journal of Endocrinology · 2018 · 896 citations · Full text

Adrenocortical Carcinoma

Tobias Else, Alex C. Kim, Aaron Sabolch et al. · Endocrine Reviews · 2013 · 871 citations · Full text

Integrated genomic characterization of adrenocortical carcinoma

Guillaume Assié, Éric Letouzé, Anne Jouinot et al. · Nature Genetics · 2014 · 716 citations

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