S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Khandaker Siddiquee, Shumin Zhang, Wayne C. Guida et al. · Proceedings of the National Academy of Sciences · 2007 · 743 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

Michele S. Redell, Marcos J. Ruiz, Todd A. Alonzo et al. · Blood · 2011 · 263 citations · Full text

Life Sciences, Oncology, Pharmacology +17

A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes

Xiaolei Zhang, Peibin Yue, Steven Fletcher et al. · Biochemical Pharmacology · 2010 · 179 citations · Full text

Life Sciences, Molecular Biology, Oncology +7

Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent

Michael Xiang, Haesook Kim, Vincent T. Ho et al. · Blood · 2016 · 113 citations · Full text

Medicine, Oncology, Pharmacology +9

Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells

Xiaoli Huang, Zhihong Zhang, Jia Li et al. · Cancer Letters · 2010 · 83 citations

Life Sciences, Cell Biology, Oncology +13