Concepedia

SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy

Mingyu Liu, Li-Juan Yue, Yingchun Luo, Jing Lu, Guodong Wu, Siqi Sheng, Yuanqi Shi, Zengxiang Dong

European Journal of Pharmacology · 2022 · 16 citations · 25 references

DOI

Concepts

References

25

A long noncoding RNA protects the heart from pathological hypertrophy

Pei Han, Wei Li, Chiou-Hong Lin et al. · Nature · 2014 · 742 citations

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Deactivation of peroxisome proliferator–activated receptor-α during cardiac hypertrophic growth

Philip M. Barger, Jon M. Brandt, Teresa C. Leone et al. · Journal of Clinical Investigation · 2000 · 462 citations · Full text

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Peroxisome Proliferator-Activated Receptor (PPAR) α and PPARβ/δ, but not PPARγ, Modulate the Expression of Genes Involved in Cardiac Lipid Metabolism

Andries J. Gilde, Karin A. J. M. van der Lee, P. H. M. Willemsen et al. · Circulation Research · 2003 · 401 citations

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Sirt1 acts in association with PPAR  to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

Anna Planavila, Roser Iglesias, Marta Giralt et al. · Cardiovascular Research · 2010 · 310 citations

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Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress

Gui-Ping Luo, Jian Zhao, Yun Zhu et al. · International Journal of Molecular Medicine · 2019 · 190 citations · Full text

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