Concepedia

Novel 1,2,3-Triazole Erlotinib Derivatives as Potent IDO1 Inhibitors: Design, Drug-Target Interactions Prediction, Synthesis, Biological Evaluation, Molecular Docking and ADME Properties Studies

Guiqing Xu, Xiaoqing Gong, Yingying Zhu, Xiaojun Yao, Lizeng Peng, Ge Sun, Jianxue Yang, Longfei Mao

Frontiers in Pharmacology · 2022 · 21 citations · 23 references

DOIFull text

Open access

Concepts

Abstract

was a novel and interesting IDO1 inhibitor for further development.

References

23

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

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DeepDTA: deep drug–target binding affinity prediction

Hakime Öztürk, Arzucan Özgür · Bioinformatics · 2018 · 1.6K citations · Full text

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Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

Xiangdong Liu, Niu Shin, Holly K. Koblish et al. · Blood · 2010 · 559 citations · Full text

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DeepPurpose: a deep learning library for drug–target interaction prediction

Kexin Huang, Tianfan Fu, Lucas M. Glass et al. · Bioinformatics · 2020 · 474 citations · Full text

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INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

Eddy W. Yue, Richard Sparks, Padmaja Polam et al. · ACS Medicinal Chemistry Letters · 2017 · 296 citations · Full text

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