Cancer Medicine · 2022 · 36 citations · 26 references
We found an inverse association between serum Klotho and cancer, but without cancer mortality. And this effect may be partially mediated by estradiol and testosterone. Further prospective studies are needed to prove these findings.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.5K citations
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations
Suppression of Aging in Mice by the Hormone Klotho
Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark et al. · Science · 2005 · 1.9K citations · Full text
Lifespan Extension, Insulin Signaling, Molecular Physiology +15
Association of human aging with a functional variant of klotho
Dan E. Arking, Alice Krebsová, Milan Maçek et al. · Proceedings of the National Academy of Sciences · 2002 · 484 citations · Full text