Concepedia

Identification of the key genes in chronic obstructive pulmonary disease by weighted gene co-expression network analysis

Zhefan Xie, Tingting Xia, Dongxue Wu, Li Che, Wei Zhang, Xingdong Cai, Shengming Liu

Annals of Translational Medicine · 2022 · 11 citations · 30 references

DOIFull text

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Abstract

We identified 8 hub genes of COPD based on GO, KEGG and WGCNA, which have provided insights into the pathophysiological mechanisms of COPD.

References

30

Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study

Chen Wang, Jianying Xu, Lan Yang et al. · The Lancet · 2018 · 1.7K citations

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Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

Deepak Kumar Vijaya Kumar, Se Hoon Choi, Kevin J. Washicosky et al. · Science Translational Medicine · 2016 · 941 citations · Full text

Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

Christina Priller, Thomas Bauer, Gerda Mitteregger et al. · Journal of Neuroscience · 2006 · 530 citations · Full text

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Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic Pulmonary Fibrosis

Annie Pardo, Kevin F. Gibson, José Cisneros et al. · PLoS Medicine · 2005 · 490 citations · Full text

Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells

Jing Dai, Ling Peng, Kexing Fan et al. · Oncogene · 2009 · 315 citations

, , +11