Concepedia

CD147 Targeting by AC-73 Induces Autophagy and Reduces Intestinal Fibrosis Associated with TNBS Chronic Colitis

Alessia Butera, Maria Teresa Quaranta, Luca Crippa, Isabella Spinello, Ernestina Saulle, Nazzareno Di Carlo, Doriana Campanile, Monica Boirivant, Catherine Labbaye

Journal of Crohn s and Colitis · 2022 · 32 citations · 25 references

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Abstract

CD147 is a potential new target for controlling intestinal fibrosis and its inhibitor, AC-73, might represent a potential new anti-fibrotic therapeutic option in IBD.

References

25

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Stefan Wirtz, Vanessa Popp, Markus Kindermann et al. · Nature Protocols · 2017 · 1.4K citations

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Natural course of Crohn's disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms.

Gunnar Olaison, Kenneth Smedh, Rune Sjödahl · Gut · 1992 · 488 citations · Full text

European Crohn’s and Colitis Organisation Topical Review on Prediction, Diagnosis and Management of Fibrostenosing Crohn’s Disease

Florian Rieder, Giovanni Latella, Fernando Magro et al. · Journal of Crohn s and Colitis · 2016 · 255 citations · Full text

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Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation

Kristina Scheibe, Christina Kersten, Anabel Schmied et al. · Gastroenterology · 2018 · 202 citations

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