Effect of <i>NOTCH3</i> EGFr Group, Sex, and Cardiovascular Risk Factors on CADASIL Clinical and Neuroimaging Outcomes

Abstract

<i>NOTCH3</i> EGFr group is the most important CADASIL disease modifier not only for age at first stroke and WMH volume but also strikingly so for a whole battery of clinically relevant disease measures such as lacune volume and peak width of skeletonized mean diffusivity. <i>NOTCH3</i> EGFr group is followed in importance by sex, hypertension, diabetes, and smoking.