Concepedia

Microwave synthesis and antimalarial screening of novel 4-amino benzoic acid (PABA)-substituted pyrimidine derivatives as Plasmodium falciparum dihydrofolate reductase inhibitors

Ayesha Aktar Khanam Choudhury, Sathishkumar Vinayagam, Nayana Adhikari, Surajit Kumar Ghosh

3 Biotech · 2022 · 12 citations · 29 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryLead OptimizationEnzyme InhibitionHigh-throughput SynthesisHit-to-lead OptimizationLead Compound DesignMicrowave-assisted SynthesisAntimalarial AgentsAntimalarial ChemotherapyAntimalarial Drug DevelopmentBenzoic Acid DerivativesPlasmodium FalciparumPyrimidine AnalogsPyrimidine AnaloguesTreatment Of Malaria

References

29

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Human Malaria Parasites in Continuous Culture

William Trager, James B. Jensen · Science · 1976 · 8K citations

Life Sciences, Biology, Infectious Diseases +15

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski · Drug Discovery Today Technologies · 2004 · 6.1K citations

Pharmacy, Chemistry, Medicinal Chemistry +14

Prediction of Drug Absorption Using Multivariate Statistics

William J. Egan, Kenneth M. Merz, John J. Baldwin · Journal of Medicinal Chemistry · 2000 · 1.9K citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

DRUG SENSITIVITY OF PLASMODIUM FALCIPARUM

Karl H. Rieckmann, Gary H. Campbell, L. J. Sax et al. · The Lancet · 1978 · 513 citations

Medicine, Pharmacology, Pharmacodynamics +9