Concepedia

Genetic encoding of ε-<i>N</i>-<scp>l</scp>-lactyllysine for detecting delactylase activity in living cells

Yanan Sun, Yanchi Chen, Yaxin Xu, Yu‐Qing Zhang, Minghao Lu, Manjia Li, Liyan Zhou, Tao Peng

Chemical Communications · 2022 · 50 citations · 30 references

DOI

Concepts

Abstract

-L-lactylated recombinant proteins and the construction of fluorescent and luminescent probes for detecting delactylases in living cells. Using these probes, we demonstrate sirtuin 1 as a potential delactylase for non-histone proteins.

References

30

Metabolic regulation of gene expression by histone lactylation

Di Zhang, Zhanyun Tang, He Huang et al. · Nature · 2019 · 3.9K citations · Full text

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Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Jie Yu, Peiwei Chai, Minyue Xie et al. · Genome biology · 2021 · 957 citations · Full text

, , +17

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

Rui‐Yuan Pan, Lin He, Ju Gao et al. · Cell Metabolism · 2022 · 798 citations

, , +17

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

Jia Xiong, Jia He, Jun Zhu et al. · Molecular Cell · 2022 · 759 citations

, , +14

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

Carlos Moreno–Yruela, Di Zhang, Wei Wei et al. · Science Advances · 2022 · 704 citations · Full text

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