Methyl eugenol protects the kidney from oxidative damage in mice by blocking the Nrf2 nuclear export signal through activation of the AMPK/GSK3β axis

Acute Kidney Injury Increases Risk of ESRD among Elderly

Areef Ishani, Jay L. Xue, Jonathan Himmelfarb et al. · Journal of the American Society of Nephrology · 2008 · 1.2K citations · Full text

Medicine, Geriatric Medicine, Nephrology +12

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Meng Zhao, Yizhuo Wang, Ling Li et al. · Theranostics · 2020 · 789 citations · Full text

Medicine, Cell Biology, Pathobiology +17

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

Anju Singh, Sreedhar Venkannagari, Kyu Hee Oh et al. · ACS Chemical Biology · 2016 · 613 citations

Medicine, Oncology, Pharmacology +16

Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression

David A. Bloom, Anil K. Jaiswal · Journal of Biological Chemistry · 2003 · 518 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

GSK-3β Acts Upstream of Fyn Kinase in Regulation of Nuclear Export and Degradation of NF-E2 Related Factor 2

Abhinav K. Jain, Anil K. Jaiswal · Journal of Biological Chemistry · 2007 · 469 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10