PKM2 regulates cigarette smoke-induced airway inflammation and epithelial-to-mesenchymal transition via modulating PINK1/Parkin-mediated mitophagy

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang, Yan Xia, Haitao Ji et al. · Nature · 2011 · 1K citations · Full text

Nuclear Pkm2, Transcriptional Regulation, Signal Transduction +6

Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

Brigitte Altenberg, Karl Otto Greulich · Genomics · 2004 · 660 citations

Tumor Biology, Tumor Heterogeneity, Cancer Classes +9

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Min Xie, Yan Yu, Rui Kang et al. · Nature Communications · 2016 · 538 citations · Full text

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

Tsuyoshi Shirai, Rafal R. Nazarewicz, Barbara B. Wallis et al. · The Journal of Experimental Medicine · 2016 · 525 citations · Full text

Immunology, Metabolic Remodeling, Coronary Artery Disease +21

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

Liangchun Yang, Min Xie, Minghua Yang et al. · Nature Communications · 2014 · 500 citations · Full text

Inflammation, Cytokine, Molecular Physiology +12