Synergistic fabrication of micro-nano bioactive ceramic-optimized polymer scaffolds for bone tissue engineering by in situ hydrothermal deposition and selective laser sintering

Abstract

Biodegradable three-dimensional porous scaffolds have attracted increasing attention as promising implants in bone tissue engineering. The micro/nano surface structure of scaffolds has also attracted significant attention due to its significant effects on scaffold physicochemical properties and cell behavior. Herein, polycaprolactone-polylactic acid-nano hydroxyapatite (PCL-PLA-nHA) ternary composite porous scaffolds with micro-nano bioactive surfaces were fabricated by combining selective laser sintering (SLS) and in situ hydrothermal deposition processes. The mechanical properties, micro/nano surface morphology, wettability, and cytocompatibility of the composite scaffolds were systematically evaluated. The results showed that the blending of PLA enhanced the compressive and tensile strength of the PCL scaffold, while also enhancing the modulus, but did not significantly change the tensile elongation. Moreover, the blending of PLA changed the fracture mode of the scaffold from ductile to brittle and its fracture mechanism was proposed. In addition, the formation mechanism of micro-nano surfaces under hydrothermal conditions was also summarized according to the micro-morphology of scaffolds. Besides, the PCL-PLA-nHA scaffold exhibited higher mineralization ability, excellent wettability, and better cytocompatibility, indicating its remarkable promise in bone tissue engineering applications.