Concepedia

CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma

Tobias Bexte, Jamal Alzubi, Lisa Marie Reindl, Philipp Wendel, Ralf Schubert, Emilia Salzmann‐Manrique, Ivana von Metzler, Toni Cathomen, Evelyn Ullrich

OncoImmunology · 2022 · 77 citations · 9 references

DOIFull text

Open access

Concepts

Abstract

-editing in primary NK cells has the prospect of overcoming immune checkpoint inhibition in clinical applications.

References

9

Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1

Ruipeng Wang, Jessica Jaw, Nicole Stutzman et al. · Journal of Leukocyte Biology · 2011 · 295 citations · Full text

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Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq

Giandomenico Turchiano, Geoffroy Andrieux, Julia Klermund et al. · Cell stem cell · 2021 · 211 citations · Full text

, , +16

High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia

Stephan Müller, Tobias Bexte, Veronika Gebel et al. · Frontiers in Immunology · 2020 · 111 citations · Full text

, , +17

Natural killer cell activity in monoclonal gammopathies: Relation to disease activity

Anders Österborg, Bo Nilsson, Magnus Björkholm et al. · European Journal Of Haematology · 1990 · 79 citations

, , +14

The Synergistic Use of IL-15 and IL-21 for the Generation of NK Cells From CD3/CD19-Depleted Grafts Improves Their ex vivo Expansion and Cytotoxic Potential Against Neuroblastoma: Perspective for Optimized Immunotherapy Post Haploidentical Stem Cell Transplantation

Annekathrin Heinze, Beatrice Grebe, Melanie Bremm et al. · Frontiers in Immunology · 2019 · 62 citations · Full text

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