Toni Cathomen

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

Desirée Schubert, Claudia Bode, Rupert Kenefeck et al. · Nature Medicine · 2014 · 805 citations · Full text

Immunogenetics, Autoimmune Disease, Immunodeficiencies +12

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

Claudio Mussolino, Robert Morbitzer, Fabienne Lütge et al. · Nucleic Acids Research · 2011 · 710 citations · Full text

Low Toxicity, Genetics, Molecular Biology +16

Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification

Morgan L. Maeder, Stacey Thibodeau-Beganny, Anna Osiak et al. · Molecular Cell · 2008 · 707 citations · Full text

Engineering, Genome Surgery, Genetic Engineering +8

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

Michal Szczepek, Vincent Brondani, Janine Büchel et al. · Nature Biotechnology · 2007 · 499 citations

Biochemistry, Natural Sciences, Metalloprotein +7

Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells

Maarten Holkers, Ignazio Maggio, Jin Liu et al. · Nucleic Acids Research · 2012 · 304 citations · Full text

Viral Replication, Genetics, Immunology +20