Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

Desirée Schubert, Claudia Bode, Rupert Kenefeck, +37

Nature Medicine

ImmunogeneticsAutoimmune DiseaseImmunodeficienciesGeneticsImmunology +10

<i>Helicobacter pylori</i> -induced peptic ulcer disease is associated with inadequate regulatory T cell responses

Karen Robinson, Rupert Kenefeck, E L Pidgeon, +5

Gut

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

Chun Jing Wang, Frank Heuts, Vitalijs Ovcinnikovs, +7

Proceedings of the National Academy of Sciences

Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation

Omar Qureshi, Satdip Kaur, Tie Zheng Hou, +8

Journal of Biological Chemistry

ImmunologyImmune RegulationAntigen ProcessingImmunotherapyCellular Physiology +14

Follicular helper T cell signature in type 1 diabetes

Rupert Kenefeck, Chun Jing Wang, Tauseef Kapadi, +11

Journal of Clinical Investigation

Type 1ImmunogeneticsSystems BiologyAutoimmune DiseaseT Cells +10

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells

Cristina Peñaranda, Wilson Kuswanto, Jerry Hofmann, +6

Proceedings of the National Academy of Sciences

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis

Kesley Attridge, Chun Jing Wang, Lukasz Wardzinski, +5

Blood

Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

Natalie M. Edner, Frank Heuts, Niclas Thomas, +15

Nature Immunology

Type 1Diabetes ManagementAutoimmune DiseaseCostimulation BlockadeInsulin Management +10

Cutting Edge: Cell-Extrinsic Immune Regulation by CTLA-4 Expressed on Conventional T Cells

Chun Jing Wang, Rupert Kenefeck, Lukasz Wardzinski, +6

The Journal of Immunology

Adaptive Immune SystemT-regulatory CellImmunologyImmune RegulationRegulatory T Cells +17

Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells

Khiyam Hussain, Darren P. Letley, A. Borgel Greenaway, +8

Frontiers in Immunology