Cell · 2022 · 166 citations · 23 references
Life SciencesImmunologyNeuroscienceAutoimmunityNeuroimmunologyStem Cell BiologyHematopoietic Stem CellsImmune Cell Lineage CommitmentMultiple SclerosisNeuroinflammationT Cell ActivationT Cell BiologyAutoreactive T Cell ResponsesBone Marrow Niche RegulationExperimental Autoimmune EncephalomyelitisImmune Cell ActivationImmune Cell Lineage SpecificationInflammatory DemyelinationMultiple Sclerosis ImmunopathogenesisT Cell Clonal Expansion
monocytes that invade the CNS. We found that myelin-reactive T cells preferentially migrate into the bone marrow compartment in a CXCR4-dependent manner. This aberrant bone marrow myelopoiesis involves the CCL5-CCR5 axis and augments CNS inflammation and demyelination. Our study suggests that targeting the bone marrow niche presents an avenue to treat MS and other autoimmune disorders.
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Comprehensive Integration of Single-Cell Data
Tim Stuart, Andrew Butler, Paul Hoffman et al. · Cell · 2019 · 16.9K citations · Full text
Fast, sensitive and accurate integration of single-cell data with Harmony
Ilya Korsunsky, Nghia Millard, Jean Fan et al. · Nature Methods · 2019 · 10.5K citations · Full text