Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity

Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity

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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

Shannon E. Mullican, Xiefan Lin‐Schmidt, Chen‐Ni Chin et al. · Nature Medicine · 2017 · 755 citations

Life Sciences, Biochemistry, Endocrinology +4

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

Linda Yang, Chih-Chuan Chang, Zhe Sun et al. · Nature Medicine · 2017 · 652 citations

Life Sciences, Biochemistry, Endocrinology +8

Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1

Heiko Johnen, Shu Lin, Támara Kuffner et al. · Nature Medicine · 2007 · 597 citations

Medicine, Cancer Biology, Oncology +14

GDF15 mediates the effects of metformin on body weight and energy balance

Anthony P. Coll, Michael Chen, Pranali Taskar et al. · Nature · 2019 · 570 citations · Full text

Life Sciences, Endocrinology, Physiology +11