In Transfusion-Dependent Thalassemia Children, Increased IronOverload is Associated with Lower Serum Alpha-Klotho, Which isStrongly Associated with Lower Total and Ionized CalciumConcentrations

Abstract

In conclusion, the iron overload in TDT and its consequences may induce lowered levels of α-Klotho which in turn may lead to lower calcium thereby explaining at least in part the effects of TDT on bone metabolism including spontaneous pathological fractures, osteoporosis, osteopenia, and skeletal deformities.