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Roflumilast, a cyclic nucleotide phosphodiesterase 4 inhibitor, protects against cerebrovascular endothelial injury following cerebral ischemia/reperfusion by activating the Notch1/Hes1 pathway

Cerebral Vascular RegulationOxidative StressInflammationThrombosisStrokeBrain InjuryNeurologyCerebral Ischemia/reperfusionAtherosclerosisNotch1/hes1 PathwayIschemic SyndromeCerebrovascular Endothelial InjuryVascular BiologyCerebral Blood FlowReperfusion InjuryPharmacologyIschemic StrokeEndothelial DysfunctionMedicine