Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway

Bingtian Xu, Yunyun Qin, Dan Li, +7

Redox Biology

Cell DeathEr StressRedox BiologyOxidative StressDegenerative Pathology +20

Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway

Bingtian Xu, Jiangping Xu, Ningbo Cai, +5

Free Radical Biology and Medicine

Ire1α/traf2/jnk PathwayGsk3β-mediated Oxidative StressIschemic StrokeStrokeMedicine +9

FCPR03, a novel phosphodiesterase 4 inhibitor, alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3β/ β-catenin signaling pathway

Bingtian Xu, Tiantian Wang, Jiao Xiao, +8

Biochemical Pharmacology

InflammationNeuroinflammationIschemic StrokeNovel Phosphodiesterase 4Medicine +11

Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult

Jiahong Zhong, Jinfeng Xie, Xiao Jiao, +8

Free Radical Biology and Medicine

Sh-sy5y CellsMitophagyNeurodegenerative DiseasesSignal TransductionCell Autophagy +11

Mitofusin 2 confers the suppression of microglial activation by cannabidiol: Insights from in vitro and in vivo models

Mengfan Li, Bingtian Xu, Xing Li, +6

Brain Behavior and Immunity

InflammationVivo ModelsMicroglial ActivationMedicineImmunology +7

Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats

Bingtian Xu, Mengfan Li, Ke-chun Chen, +4

Acta Pharmacologica Sinica

Cerebral IschemiaCerebral Vascular RegulationNeuropharmacologyBrain InjuryNeuroscience +6

Inhibition of PDE4 Attenuates TNF-α-Triggered Cell Death Through Suppressing NF-κB and JNK Activation in HT-22 Neuronal Cells

Jiao Xiao, Rumeng Yao, Bingtian Xu, +6

Cellular and Molecular Neurobiology

Neurodegenerative DiseasesSignal TransductionMedicineApoptosisImmune Regulation +12

Roflumilast, a cyclic nucleotide phosphodiesterase 4 inhibitor, protects against cerebrovascular endothelial injury following cerebral ischemia/reperfusion by activating the Notch1/Hes1 pathway

Ningbo Cai, Bingtian Xu, Xing Li, +5

European Journal of Pharmacology

Cerebral Vascular RegulationOxidative StressInflammationThrombosisStroke +14

Involvement of CKS1B in the anti-inflammatory effects of cannabidiol in experimental stroke models

Kechun Chen, Bingtian Xu, Xuan Xiao, +7

Experimental Neurology

InflammationThrombosisCerebral Vascular RegulationExperimental Stroke ModelsMedicine +13