Concepedia

Azole Resistance-Associated Regulatory Motifs within the Promoter of <i>cyp51A</i> in Aspergillus fumigatus

Alexander Kühbacher, Mandy Peiffer, Peter Hortschansky, Petra Merschak, Michael Bromley, Hubertus Haas, Axel A. Brakhage, Fabio Gsaller

Microbiology Spectrum · 2022 · 17 citations · 21 references

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Concepts

Abstract

First-line treatment of aspergillosis typically involves the use of azole antifungals. Worryingly, their future clinical use is challenged by an alarming increase in resistance.

References

21

Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline

Andrew J. Ullmann, José María Aguado, David W. Denning et al. · Clinical Microbiology and Infection · 2018 · 1.5K citations · Full text

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A New <i>Aspergillus fumigatus</i> Resistance Mechanism Conferring In Vitro Cross-Resistance to Azole Antifungals Involves a Combination of <i>cyp51A</i> Alterations

Emilia Mellado, Guillermo García‐Effrón, Laura Alcázar‐Fuoli et al. · Antimicrobial Agents and Chemotherapy · 2007 · 498 citations · Full text

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Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles

Jan W. M. van der Linden, Simone M. T. Camps, Greetje A. Kampinga et al. · Clinical Infectious Diseases · 2013 · 347 citations · Full text

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HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

Markus Schrettl, Nicola Beckmann, John Varga et al. · PLoS Pathogens · 2010 · 290 citations · Full text

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Interaction of HapX with the CCAAT‐binding complex—a novel mechanism of gene regulation by iron

Peter Hortschansky, Martin Eisendle, Qusai Al Abdallah et al. · The EMBO Journal · 2007 · 229 citations · Full text

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