Synthesis and Biological Studies of Inducible DNA Cross‐Linking Agents

Abstract

Checking the traps: When a phenyl selenide compound such as 1 was oxidized with sodium periodate or irradiated, an ortho-quinone methide intermediate formed and reacted with a DNA duplex by cross-linking. In the crystal structure of a derivative of 1 the biphenyl unit is twisted, and this might explain how 1 can interact effectively with the DNA backbone. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700844_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.