Alkylation of Nucleic Acids by a Model Quinone Methide

Praveen Pande, Jason Shearer, Jianhong Yang, +2

Journal of the American Chemical Society

Intrinsic ReactivityMedicinal ChemistryNucleic Acid ChemistryBioorganic ChemistryBiochemistry +12

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

Jianhong Yang, Yuxi Wang, Taijing Wang, +8

Nature Communications

Quinone Methide Alkylation of Deoxycytidine

Steven E. Rokita, Jianhong Yang, Praveen Pande, +1

The Journal of Organic Chemistry

Derivative (Chemistry)Molecular SciencesBioorganic ChemistryHeterocyclicBiochemistry +11

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

Wei Yang, Xiaolong Liu, Chunli Song, +10

European Journal of Medicinal Chemistry

Medicinal ChemistryTherapeutic EffectIschemic Stroke ModelBiochemistryMedicine +9

The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin

Jianhong Yang, Wei Yan, Yamei Yu, +17

Journal of Biological Chemistry

Protein ChemistryBiochemistryCompound MillepachineNatural SciencesMedicine +7

Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity

Lu Niu, Jianhong Yang, Wei Yan, +5

Journal of Biological Chemistry

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Jianhong Yang, Yamei Yu, Yong Li, +16

Science Advances

Cytotoxic and apoptotic effects of constituents from Millettia pachycarpa Benth

Haoyu Ye, Afu Fu, Wenshuang Wu, +11

Fitoterapia

AllergyBotanyMedicineHerb-drug InteractionMillettia Pachycarpa Benth +5

Synthesis and Biological Evaluation of Novel Millepachine Derivatives As a New Class of Tubulin Polymerization Inhibitors

Zhuang Yang, Wenshuang Wu, Jingjing Wang, +15

Journal of Medicinal Chemistry

NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation

Xueqin Jiang, Xinlu Zhang, Xiaoying Cai, +12

Science Advances

ImmunologyGasdermin DMolecular BiologyChemical BiologyInflammation +16