Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

Zhenhua Shao, Wei Yan, Karen Chapman, +6

Nature Chemical Biology

Allosteric Modulator BoundMolecular PharmacologyCb1 Cannabinoid ReceptorCannabis UseBiochemistry +8

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Peng Xiao, Wei Yan, Lu Gou, +26

Cell

Signal TransductionSignaling PathwayMolecular RegulationG Protein-coupled ReceptorLigand Recognition +3

Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway

Juan Wang, Xu-mei Li, Zhun Bai, +3

Journal of Ethnopharmacology

Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1

Xin Yang, Xuehui Wang, Zheng Xu, +13

Nature Chemical Biology

Cannabis UseMolecular PharmacologyCannabinoid Receptor Cb1Signal TransductionBiochemistry +10

Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition

Yuan Yuan, Guowen Jia, Chao Wu, +9

Cell Research

Proteinlipid InteractionDrug TargetSignal TransductionBiochemistryFunctional Selectivity +8

The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin

Jianhong Yang, Wei Yan, Yamei Yu, +17

Journal of Biological Chemistry

Protein ChemistryBiochemistryCompound MillepachineNatural SciencesMedicine +7

Ligand recognition and G-protein coupling of trace amine receptor TAAR1

Zheng Xu, Lulu Guo, Jingjing Yu, +27

Nature

Signal TransductionBiochemistryG Protein-coupled ReceptorNatural SciencesFunctional Selectivity +6

Curcumol induces cell cycle arrest and apoptosis by inhibiting IGF‐1R/PI3K/Akt signaling pathway in human nasopharyngeal carcinoma CNE‐2 cells

Xumei Li, Haowei Liu, Juan Wang, +5

Phytotherapy Research

OncologyChemoprevention StrategyCell SignalingCycle ArrestMedicine +13

Molecular mechanism of agonism and inverse agonism in ghrelin receptor

Jiao Qin, Ye Cai, Zheng Xu, +11

Nature Communications

Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode

Wei Yan, Lin Cheng, Wei Wang, +9

Nature Communications