High-resolution crystal structure of the human CB1 cannabinoid receptor

Zhenhua Shao, Jie Yin, Karen Chapman, +4

Nature

Cannabis UseMolecular PharmacologyHigh-resolution Crystal StructureBiochemistryNatural Sciences +7

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

Zhenhua Shao, Wei Yan, Karen Chapman, +6

Nature Chemical Biology

Allosteric Modulator BoundMolecular PharmacologyCb1 Cannabinoid ReceptorCannabis UseBiochemistry +8

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Peng Xiao, Wei Yan, Lu Gou, +26

Cell

Signal TransductionSignaling PathwayMolecular RegulationG Protein-coupled ReceptorLigand Recognition +3

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Jie Yin, Kerim Babaoglu, Chad A. Brautigam, +10

Nature Structural & Molecular Biology

Human Ox1Signal TransductionMolecular PhysiologyBiochemistryLigand-binding Mechanism +9

Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1

Xin Yang, Xuehui Wang, Zheng Xu, +13

Nature Chemical Biology

Cannabis UseMolecular PharmacologyCannabinoid Receptor Cb1Signal TransductionBiochemistry +10

Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition

Yuan Yuan, Guowen Jia, Chao Wu, +9

Cell Research

Proteinlipid InteractionDrug TargetSignal TransductionBiochemistryFunctional Selectivity +8

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

Wei Yang, Xiaolong Liu, Chunli Song, +10

European Journal of Medicinal Chemistry

Medicinal ChemistryTherapeutic EffectIschemic Stroke ModelBiochemistryMedicine +9

Matrix metalloproteinase-3 (stromelysin-1). Identification as the cartilage acid metalloprotease and effect of pH on catalytic properties and calcium affinity.

S M Wilhelm, Zhenhua Shao, Timothy J Housley, +4

Journal of Biological Chemistry

Tissue EngineeringMolecular BiologyMusculoskeletal ResearchInflammationBone Morphogenic Protein +16

Ligand recognition and G-protein coupling of trace amine receptor TAAR1

Zheng Xu, Lulu Guo, Jingjing Yu, +27

Nature

Signal TransductionBiochemistryG Protein-coupled ReceptorNatural SciencesFunctional Selectivity +6

Mechanism of activation and biased signaling in complement receptor C5aR1

Yuying Feng, Chang Zhao, Yue Deng, +10

Cell Research