Total Chemical Synthesis of Di‐ubiquitin Chains

Abstract

Wie man Ketten bildet zeigt ein allgemeiner und effektiver Weg zur chemischen Totalsynthese aller Diubiquitin-Ketten (siehe Bild). Das Verhalten der synthetisierten Ketten in Gegenwart von Isopeptidase T, einem Enzym, das die meisten nichtverankerten Polyubiquitine in vivo zerlegt, wurde untersucht. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.