Concepedia

Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1

Michael P. Dwyer, Kamil Paruch, Marc Labroli, Carmen Álvarez, Kerry Keertikar, Cory Poker, Randall R. Rossman, Thierry Fischmann, José S. Duca, Vincent Madison,

Bioorganic & Medicinal Chemistry Letters · 2010 · 69 citations · 8 references

DOI

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References

8

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

Sonya Zabludoff, Chun Deng, Michael Grondine et al. · Molecular Cancer Therapeutics · 2008 · 410 citations · Full text

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Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1

Alessandra Blasina, Jill Hallin, Enhong Chen et al. · Molecular Cancer Therapeutics · 2008 · 226 citations · Full text

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Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases

Kamil Paruch, Michael P. Dwyer, Carmen Álvarez et al. · ACS Medicinal Chemistry Letters · 2010 · 175 citations

, , +10

The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106

Michael I. Walton, Paul D. Eve, Angela Hayes et al. · Molecular Cancer Therapeutics · 2010 · 101 citations · Full text

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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 2

Marc Labroli, Kamil Paruch, Michael P. Dwyer et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 74 citations · Full text

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