Ag^I Ion Mediated Formation of a C–A Mispair by DNA Polymerases

Abstract

Mit Silber zu A–C: In Gegenwart von AgI-Ionen baut eine DNA-Polymerase Desoxyadenosin (aus dATP) gegenüber einem Cytosinrest im Templatstrang unter Bildung des Volllängenprodukts ein (siehe Schema). Das bedeutet, dass DNA-Polymerasen ein C-AgI-A-Basenpaar dem thermodynamisch stabileren C-AgI-C-Basenpaar vorziehen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.