Journal of Clinical Investigation · 2002 · 265 citations · 28 references
Life SciencesBiochemistryEndocrinologyMetabolic PhysiologyMetabolic RegulationMetabolismAdipose TissueInsulin ResistanceLipid MetabolismMetabolic DisordersMetabolic SyndromeTriglyceride MetabolismDiacylglycerol AcyltransferaseDiacylglycerol MetabolismEnergy Expenditure AlterationInsulin PhysiologyLeptin ResistanceObesity MetabolismObesity-associated Insulin ResistanceTriglyceride Synthesis
MethodsMice.Dgat1 -/-mice (95% C57BL/6 and 5% 129/SvJae background) were generated previously (4).Wild-type (Dgat1 +/+ ), ob/+, and A Y /a mice (all in C57BL/6 background) were from the The Jackson Laboratory (Bar Harbor, Maine, USA).A Y /a mice are obese and insulin resistant, reflecting the antagonism of melanocyte-
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