Annual Review of Immunology · 1989 · 114 citations · 0 references
Life SciencesCell BiologyImmunologyCancer ImmunologyCellular ImmunologyInnate ImmunityCell-mediated ImmunityEffector T Cell FunctionImmune Cell SignalingT Cell ActivationT Cell BiologyT Cell ExhaustionAnimal Disease ModelsCd8 T Cell ActivationCytokine-driven T Cell DifferentiationCytokine-mediated T Cell ActivationCytokine-mediated T Cell ResponsesInhibitory Molecule ExpressionT-cell Mediated ResponsesT-cell Regulation
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More