Concepedia
Bioorganic & Medicinal Chemistry · 2006 · 39 citations · 20 references
Medicinal ChemistryMedicineRational Drug DesignPharmacologyPharmaceutical ChemistryRho Kinase InhibitorsDrug Discovery
20
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
Masayoshi Uehata, Toshimasa Ishizaki, Hiroyuki Satoh et al. · Nature · 1997 · 2.9K citations
Hypertension, Muscle Function, Signal Transduction +11
Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo
Yoji Kawano, Yuko Fukata, Noriko Oshiro et al. · The Journal of Cell Biology · 1999 · 554 citations · Full text
Tpa Stimulation, Cytoskeleton, Cellular Physiology +17
Suppression of Coronary Artery Spasm by the Rho-Kinase Inhibitor Fasudil in Patients With Vasospastic Angina
Akihiro Masumoto, Masahiro Mohri, Hiroaki Shimokawa et al. · Circulation · 2002 · 455 citations · Full text
Use and properties of ROCK-specific inhibitor Y-27632
Shuh Narumiya, Toshimasa Ishizaki, Masayoshi Ufhata · Methods in enzymology on CD-ROM/Methods in enzymology · 2000 · 328 citations
Molecular Pharmacology, Medicine, Mechanism Of Action +4
Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway
Kanchan Chitaley, Christopher J. Wingard, R. Clinton Webb et al. · Nature Medicine · 2001 · 309 citations
Urology, Molecular Neuroscience, Erectile Dysfunction +7