Concepedia

Total Synthesis of Ambruticin

Eun Lee, Seung Jib Choi, Hahn Kim, Hee Oon Han, Young Keun Kim, Sun‐Joon Min, Sung Hee Son, Sang Min Lim, Won Suk Jang

Angewandte Chemie · 2002 · 16 citations · 28 references

DOI

Concepts

Abstract

Radikalcyclisierung und Ringschlussmetathese wurden als Schlüsselschritte einer konvergenten Totalsynthese des oral wirksamen Antimykotikums Ambruticin 1 für den Aufbau der beiden Oxacyclen genutzt.

References

28

Synthesis and Applications of RuCl<sub>2</sub>(CHR‘)(PR<sub>3</sub>)<sub>2</sub>:  The Influence of the Alkylidene Moiety on Metathesis Activity

Peter Schwab, Robert H. Grubbs, Joseph W. Ziller · Journal of the American Chemical Society · 1996 · 2.1K citations

, , +16

A Stereoselective Synthesis of<i>trans</i>-1,2-Disubstituted Alkenes Based on the Condensation of Aldehydes with Metallated 1-Phenyl-1<i>H</i>-tetrazol-5-yl Sulfones

Paul R. Blakemore, W.J. Cole, Philip Kocieński et al. · Synlett · 1998 · 698 citations

, , +5

An Asymmetric Aldol−Ring-Closing Metathesis Strategy for the Enantioselective Construction of Oxygen Heterocycles:  An Efficient Approach to the Enantioselective Synthesis of (+)-Laurencin

Michael T. Crimmins, Allison L. Choy · Journal of the American Chemical Society · 1999 · 159 citations

, , +17

A Convenient Method for Removing All Highly-Colored Byproducts Generated during Olefin Metathesis Reactions

Leo A. Paquette, Jeffrey D. Schloss, Ivan Efremov et al. · Organic Letters · 2000 · 147 citations

, , +12

Ambruticin (W7783), a new antifungal antibiotic.

Samuel M. Ringel, R. Clive Greenough, S Roemer et al. · The Journal of Antibiotics · 1977 · 139 citations · Full text

, , +9