A Stereoselective Synthesis of<i>trans</i>-1,2-Disubstituted Alkenes Based on the Condensation of Aldehydes with Metallated 1-Phenyl-1<i>H</i>-tetrazol-5-yl Sulfones - Concepedia

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A Stereoselective Synthesis of<i>trans</i>-1,2-Disubstituted Alkenes Based on the Condensation of Aldehydes with Metallated 1-Phenyl-1<i>H</i>-tetrazol-5-yl Sulfones

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References

1998

Year

Paul R. Blakemore, W.J. Cole, Philip Kocieński, Andrew Morley

Chemical EngineeringEngineeringHeterocyclicAlkene MetathesisMetallated 1-Phenyl-1h-tetrazol-5-yl SulfonesOrganic ChemistryTrans-1,2-disubstituted AlkenesCatalysisStereoselective SynthesisChemistrySodium HexamethyldisilazideEnantioselective Synthesis

Abstract

The reaction of metallated 1-phenyl-1H-tetrazol-5-yl sulfones and aldehydes gives good yields and stereoselectivity of trans-1,2-disubstituted alkenes when potassium or sodium hexamethyldisilazide is used as base and 1,2-dimethoxyethane is used as solvent.