Nucleic Acids Research · 2013 · 2K citations · 24 references
Life SciencesBioinformaticsBiomedical InformaticsComputational BiologyPathway AnalysisProteomicsDisease Network BiologyPathway AnnotationPathway DatabasesProtein Database SearchCurated Pathway ResourcesDisease Pathway DatabasesPathway Database ConstructionPathway DiscoveryPathway Knowledge BasesPathway KnowledgebasesProteome BioinformaticsReaction Pathway Databases
Reactome (http://www.reactome.org) is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to support annotation of disease processes due to infectious agents and to mutation.
24
Helen M. Berman · Nucleic Acids Research · 2000 · 39.8K citations
KEGG for integration and interpretation of large-scale molecular data sets
Minoru Kanehisa, Susumu Goto, Yoko Sato et al. · Nucleic Acids Research · 2011 · 5K citations · Full text
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Andrew V. Biankin, Nicola Waddell, Karin S. Kassahn et al. · Nature · 2012 · 2.1K citations · Full text