IUPHAR/BPS Guide to Pharmacology CITE · 2019 · 14 citations · 516 references
Natural SciencesBiochemistryPharmacologyElectrophysiologyIon Channel BiophysicsMolecular PharmacologyChannel StructureIon Channel PharmacologyIon Channel PhysiologyIon Channel RegulationIon ChannelsPotassium Channel BiophysicsChannelsIon Channel Subunit CompositionPotassium Channel FunctionPotassium Channel GatingPotassium Channel PharmacologyPotassium Channel PhysiologyVoltage-gated ChannelsVoltage-gated Potassium Channels
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.
516
The Transcriptional Landscape of the Mammalian Genome
Piero Carninci, Takeya Kasukawa, Shintaro Katayama et al. · Science · 2005 · 3.6K citations
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
Mark Curran, Igor Splawski, Katherine W. Timothy et al. · Cell · 1995 · 2.3K citations · Full text
Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel
Michael C. Sanguinetti, Mark Curran, Anruo Zou et al. · Nature · 1996 · 1.8K citations
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
Q. Wang, Mark Curran, Igor Splawski et al. · Nature Genetics · 1996 · 1.8K citations