Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

Abstract

(Immunity 47, 875–889, November 21, 2017) The authors have noticed a reversal of labels identifying experimental treatment of samples analyzed by flow cytometry in Figure 3G. The left hand panels should have been labeled as IsC (isotype control) while the right hand panels should have been labeled as CD28. The authors apologize for any inconvenience they have created.Figure 3GCD28-Induced Migration and Metabolic Reprogramming Require PI3K but Not mTORC-1 Activation (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated GlycolysisKishore et al.ImmunityNovember 21, 2017In BriefRegulatory T cell localization to inflammatory sites is key to their homeostatic function. Kishore and colleagues demonstrate that Treg cell migration requires the activation of glycolysis by the enzyme glucokinase induced via a Treg cell-selective PI3K-mTORC2 pathway. Full-Text PDF Open Access