Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis

Abstract

Our data indicate that Th1-like Treg cells are the predominant Treg cell subset in RA SF, but their suppressive function is defective. Improving the function of Th1-like Treg cells may control inflammation in joints and provide new strategies for Treg-targeted therapies in RA.