Concepedia

Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation

Julia Katharina Scholz, Andre Kraus, Dominik Lüder, Kathrin Skoczynski, Mario Schiffer, Steffen Grampp, Johannes Schödel, Bjoern Buchholz

iScience · 2022 · 17 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

, cAMP impaired tubule formation after capillary-induced injury which was further impaired by loss Polycystin-1.

References

30

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

Vicente E. Torres, Arlene B. Chapman, Olivier Devuyst et al. · New England Journal of Medicine · 2012 · 1.6K citations · Full text

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Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist

Vincent H. Gattone, Xiaofang Wang, Peter C. Harris et al. · Nature Medicine · 2003 · 669 citations

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c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function

Jacqueline S. Biscardi, Ming‐Chei Maa, David A. Tice et al. · Journal of Biological Chemistry · 1999 · 645 citations · Full text

, , +13

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

Yuhei Kirita, Kohei Uchimura, Parker C. Wilson et al. · Proceedings of the National Academy of Sciences · 2020 · 633 citations · Full text

, , +17

Vertebrate kidney tubules elongate using a planar cell polarity–dependent, rosette-based mechanism of convergent extension

Soeren S. Lienkamp, Kun Liu, Courtney M. Karner et al. · Nature Genetics · 2012 · 239 citations · Full text

, , +17