Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

Bhushan Nagar, William G. Bornmann, Patricia Pellicena et al. · PubMed · 2002 · 940 citations

Crystal Structure, Mixed-phenotype Acute Leukemia, Molecular Biology +18

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Catherine C. Smith, Qi Wang, Chen-Shan Chin et al. · Nature · 2012 · 734 citations

Hematological Malignancy, Medicine, Mixed-phenotype Acute Leukemia +10

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl Cramer et al. · Blood · 2009 · 630 citations · Full text

Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase

Clifford D. Mol, Douglas R. Dougan, T. Schneider et al. · Journal of Biological Chemistry · 2004 · 614 citations · Full text

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

Chunaram Choudhary, Jesper V. Olsen, Christian Brandts et al. · Molecular Cell · 2009 · 313 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +5