STopTox: An <i>in Silico</i> Alternative to Animal Testing for Acute Systemic and Topical Toxicity

Abstract

We developed STopTox, a comprehensive collection of computational models that can be used as an alternative to <i>in vivo</i> 6-pack tests for predicting the toxicity hazard of small organic molecules. Models were established following the best practices for the development and validation of QSAR models. Scientists and regulators can use the STopTox portal to identify putative toxicants or nontoxicants in chemical libraries of interest. https://doi.org/10.1289/EHP9341.