Conventional and microwave-assisted synthesis, anticancer evaluation, 99mTc-coupling and In-vivo study of some novel pyrazolone derivatives

Liquid‐Assisted Grinding Mechanochemistry in the Synthesis of Pharmaceuticals

Ping Ying, Jingbo Yu, Weike Su · Advanced Synthesis & Catalysis · 2021 · 334 citations

Materials Science, Engineering, Abstract Mechanochemical Reactions +11

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

Brian Dymock, Xavier Barril, Paul A. Brough et al. · Journal of Medicinal Chemistry · 2005 · 231 citations · Full text

Crystal Structure, Drug Target, Molecular Biology +18

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

Kwai-Ming J. Cheung, Thomas P. Matthews, Karen James et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 219 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +10

4-Arylazo-3,5-diamino-1<i>H</i>-pyrazole CDK Inhibitors:  SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects

Vladimı́r Kryštof, Petr Cankař, Iveta Fryšová et al. · Journal of Medicinal Chemistry · 2006 · 191 citations · Full text

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

J. Scott Sawyer, Douglas W. Beight, Karen S. Britt et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 161 citations

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +9