Concepedia

A novel PHD2 inhibitor acteoside from Cistanche tubulosa induces skeletal muscle mitophagy to improve cancer-related fatigue

Shilei Zhang, Fukai Gong, Jiali Liu, Tao Liu, Jianhua Yang, Junping Hu

Biomedicine & Pharmacotherapy · 2022 · 22 citations · 14 references

DOIFull text

Open access

Abstract

These results suggest that ACT can improve CRF by promoting mitophagy via suppression of PHD2 to remove dysfunctional mitochondria, demonstrating that ACT has huge prospects for clinical application in CRF treatment.

References

14

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, , +8

Anti-hyperglycemic and hypolipidemic effects of Cistanche tubulosa in type 2 diabetic db/db mice

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, , +11

Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment

Xu Wang, Jie Mao, Tao Zhou et al. · Theranostics · 2020 · 53 citations · Full text