Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Wei Qi, Homan Chan, Lin Teng, +24

Proceedings of the National Academy of Sciences

Selective InhibitionTumor BiologyMethyl GroupLymphoid NeoplasiaOncology +13

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

Nan Song, Zhao-Shan Liu, Wen Xue, +15

Molecular Cell

InflammationSignal TransductionSignaling PathwayImmunologyChronic Inflammation +8

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

Jiang Dai, Yi-Jiao Huang, Xinhua He, +24

Cell

Autoimmune DiseaseAutoantibody ProductionImmunologyAutoimmunityAutoantibodies +2

G3BP1 promotes DNA binding and activation of cGAS

Zhao-Shan Liu, Hong Cai, Wen Xue, +20

Nature Immunology

Transcriptional RegulationMolecular PhysiologyDna BindingMolecular RegulationNatural Sciences +7

Toward an understanding of the protein interaction network of the human liver

Jian Wang, Keke Huo, Lixin Ma, +35

Molecular Systems Biology

Protein Interaction NetworkEngineeringBiochemistryInteractomicsProtein Folding +11

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Yuan Lin, Yanrong Lv, Hongchang Li, +14

Nature Cell Biology

Signal TransductionSignaling PathwayPten StabilityTumor SuppressorMedicine +3

The promotion of bone regeneration through positive regulation of angiogenic–osteogenic coupling using microRNA-26a

Yan Li, Longkun Fan, Shiyu Liu, +8

Biomaterials

Regenerative MedicineDevelopmental BiologyPositive RegulationMedicineBone Regeneration +4

AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression

Haixin Zhao, Teng Li, Kai Wang, +14

Nature Cell Biology

MitophagySignal TransductionCell DivisionMitochondrial FunctionAmpk-mediated Activation +9

Analysis of PD1, PDL1, PDL2 expression and T cells infiltration in 1014 gastric cancer patients

Xiaofang Xing, Jianping Guo, Guangyu Ding, +23

OncoImmunology

ImmunologyGastroenterologyPathologyImmune Checkpoint BlockadeImmunotherapy +14

Induction of SOX4 by DNA damage is critical for p53 stabilization and function

Xin Pan, Jie Zhao, Wei-Na Zhang, +10

Proceedings of the National Academy of Sciences

Genome InstabilityDna DamageSox4 ExpressionCell RegulationNatural Sciences +13