Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking

Abstract

The active ingredients of <i>Cordyceps</i> <i>sinensis</i> may exert antidepressant effects by regulating the CREB binding protein and anti-oxidative stress effects. The <i>foxo</i> signaling pathway (hsa04068), hypoxia-inducible factor 1 (HIF-1) signaling pathway (hsa04066), and Huntington's disease (hsa05016) may be involved in the underlying mechanisms of <i>Cordyceps</i> <i>sinensis</i>. The joint application of network pharmacology and molecular docking provides a new approach to study the mechanisms of action of traditional Chinese medicine. <i>Cordyceps sinensis</i> may play an important role in the future treatment of patients with depression.