American Journal of Physiology-Renal Physiology · 2022 · 20 citations · 36 references
Life SciencesCell BiologyMolecular BiologyApoptosisCell SignalingSignal TransductionAcute Kidney InjuryCellular Responses To HypoxiaHypoxia AdaptationRenal IschemiaRenal Ischemic InjuryTissue RepairAcute Kidney Injury PathophysiologyHif-1 Alpha RegulationHif-2 Alpha RegulationHypoxia-inducible Factor ActivationHypoxia-inducible Factor RegulationHypoxia-inducible Factor SignalingHypoxia-reoxygenation InjuryRenal Responses To Hypoxia
We investigated the role of hypoxia-inducible factor (HIF) in acute kidney injury in vivo and in vitro. Expression of HIF in the adaptive repair group was more rapid and sufficient than that in the maladaptive repair group during the early repair phase. HK-2 and EA.hy926 cells treated with hypoxia/reoxygenation were used to elucidate the cross talk between HIF and the Wnt/β-catenin signaling pathway by which HIF played a renoprotective role in acute kidney injury.
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Macrophage Wnt7b is critical for kidney repair and regeneration
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