Novel Combination Therapy for Extensively Drug-Resistant <i>Acinetobacter baumannii</i> Necrotizing Pneumonia Complicated by Empyema: A Case Report

Abstract

We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant <i>Acinetobacter baumannii</i> necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.